Proteometer-L Kit
​The Proteometer-L Kit transforms any LC into an analytical system capable of identifying and quantifying titer and relative aggregate content in crude culture filtrate in <10 minutes, without sample preparation.
It works with mAbs, multi-specifics, and recombinant proteins containing an Fc domain and eliminates sample preparation and method development.
Features & Benefits
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mAb titer + aggregate measurement: One assay for two critical attributes
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No Protein A purification required: Reduces costs
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No sample pretreatment: Reduces hours of sample prep
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Direct analysis from CFB: HCP removal is not needed
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No method development: Reduces time until method development
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Plug-and-play kit for any LC: Easy adoption - no software needed
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Low sample volume (≤ 10μL): Reduced impact on processing
Kit Components
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Proteometer-L Reactor
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Proteometer-L Reagent
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Proteometer-L Buffer
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Proteometer-L Reconstitution Reagent
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Instructions for Use​​
At-line Applications:
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Drug Discovery
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Clone Selection
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High Throughput Screening
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Product Characterization
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PR&D and Manufacturing
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Additional Product Information
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TESTIMONIALS
"We use the Proteometer-L Kit for the rapid analysis of mAbs and bispecifics for titer and aggregate content from cell-free filtrate samples.
It eliminates sample preparation steps, Protein A purification, and mass spectrometry analysis steps.
I would recommend the Proteometer to any pharmaceutical company to quickly and accurately quantitate mAb titer and aggregate content."
Harsha Gunawardena
Senior Principal Scientist
Johnson & Johnson
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“Novilytic’s Proteometer is a disruptive breakthrough that finally solves the FDA's requirement to continuously monitor t-mAb proteoforms during fermentation.
The approach improves product safety, reduces COPQ and post release testing, and paves the way for real-time product release, reducing inventory costs.
The solution combines novel sample handing and artificial intelligence with proven analytical technology that is easy to deploy and support, and provides near instantaneous ROI.”
Martin Long, BSc.
Performance Validation, Inc. – President & CEO
(Analytical Sciences Business, Brooks Life Sciences, Thermo, Perkin Elmer)
"As analytical tools have matured for the quality control and characterization of isolated biopharmaceuticals, the application of advanced analytical systems to dynamically contribute to process monitoring and control in complex bioreactors is critical for enhanced process efficiency and product quality.
The Proteometer is expected to play a central role in the development and commercialization of next-level biological manufacturing control strategies. The integration of complementary bioprocess analytical data facilitates decision-making through a powerful link between the manufacturing space and the QC laboratory."